Antofagasta to La Serena Flights from HKD 23 incl. tax

Based on HopeGoo data, Sky Airline offers one-way fares as low as US$21 on Cheapest nonstop routes (e.g. ANF to LSC on Wed, Mar 18), while JetSMART Airlines offers Cheapest nonstop round-trips from US$52 departing on Fri, Mar 13 and returning on Mon, Mar 16.

At the moment, you can catch a nonstop flight from Antofagasta to La Serena with the following airlines, including: Sky Airline Selected airlines are based on historical data collected from flight bookings users made on HopeGoo within the last 90 days.

It takes about 1 hour 26 minutes to fly from Antofagasta to La Serena.

By analyzing data from all airlines on the HopeGoo flight calendar, it looks like the best time to book a flight from Antofagasta to La Serena is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

Based on HopeGoo data in the past 4 weeks, there is 3 flight per week flying from Antofagasta to La Serena. You can check the weekly schedule for popular airlines on this route below: Sky Airline: -/-/-/W/-/-/- -- H2351 (07:30)

To find best deals on flights from Antofagasta to La Serena, you can use various tools on HopeGoo: · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Wed, Mar 18, with one-way flights priced at just US$21. · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Sky Airline. · Set up price alerts to easily monitor ticket prices without having to check every day. · Check HopeGoo flight deals and promo codes frequently. · Avoid peak season unless you book very early. It seems the peak season for La Serena travel is around January. · Get exclusive promo codes for HopeGoo app users.

The cheapest months to fly from Antofagasta to La Serena is September, when demand for travel is lower.

After crunching the numbers on our February flight calendar, it's currently cheapest to fly from Antofagasta to La Serena on February 19, 2026 with Sky Airline, with prices starting at US$80.

You can land at any one of the following hubs in La Serena, with Andres Sabella Airport to La Florida Airport (ANF-LSC) is by far the most common option on this route: La Florida Airport (LSC).

The time difference between La Serena and Antofagasta is 0h.

Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your HopeGoo, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.