Cusco to Guayaquil Flights from US$143 incl. tax

Based on HopeGoo data, avianca offers one-way fares as low as US$162 on Cheapest nonstop routes (e.g. CUZ to GYE on Wed, Feb 25), while LATAM Airlines offers Cheapest nonstop round-trips from US$378 departing on Tue, Mar 17 and returning on Tue, Mar 24.

At the moment, you can catch a nonstop flight from Cusco to Guayaquil with the following airlines, including: LATAM Airlines Selected airlines are based on historical data collected from flight bookings users made on HopeGoo within the last 90 days.

By analyzing data from all airlines on the HopeGoo flight calendar, it looks like the best time to book a flight from Cusco to Guayaquil is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

To find best deals on flights from Cusco to Guayaquil, you can use various tools on HopeGoo: · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Wed, Feb 25, with one-way flights priced at just US$162. · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is avianca. · Set up price alerts to easily monitor ticket prices without having to check every day. · Check HopeGoo flight deals and promo codes frequently. · Avoid peak season unless you book very early. It seems the peak season for Guayaquil travel is around January. · Get exclusive promo codes for HopeGoo app users.

The cheapest months to fly from Cusco to Guayaquil is October, when demand for travel is lower.

After crunching the numbers on our February flight calendar, it's currently cheapest to fly from Cusco to Guayaquil on February 25, 2026 with avianca, with prices starting at US$162.

You can land at any one of the following hubs in Guayaquil, with Alejandro Velasco Astete International Airport to Jose Joaquin De Olmedo International Airport (CUZ-GYE) is by far the most common option on this route: Jose Joaquin De Olmedo International Airport (GYE).

The time difference between Guayaquil and Cusco is 0h.

Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your HopeGoo, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.