Return flights from La Serena to Santiago Flights from HKD 13 incl. tax

Based on HopeGoo data, JetSMART Airlines offers one-way fares as low as US$22 on Cheapest nonstop routes (e.g. LSC to SCL on Fri, Apr 3), while Sky Airline offers Cheapest nonstop round-trips from US$42 departing on Mon, Mar 2 and returning on Mon, Mar 9.

At the moment, you can catch a nonstop flight from La Serena to Santiago with the following airlines, including: LATAM Airlines Sky Airline Selected airlines are based on historical data collected from flight bookings users made on HopeGoo within the last 90 days.

It takes about 59 minutes to fly from La Serena to Santiago.

By analyzing data from all airlines on the HopeGoo flight calendar, it looks like the best time to book a flight from La Serena to Santiago is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

Based on HopeGoo data in the past 4 weeks, there is 60 flight per week flying from La Serena to Santiago. You can check the weekly schedule for popular airlines on this route below: LATAM Airlines: S/M/T/W/T/F/S -- LA101 (10:30) LATAM Airlines: S/-/-/W/T/F/S -- LA105 (19:07)

To find best deals on flights from La Serena to Santiago, you can use various tools on HopeGoo: · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Fri, Apr 3, with one-way flights priced at just US$22. · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is JetSMART Airlines. · Set up price alerts to easily monitor ticket prices without having to check every day. · Check HopeGoo flight deals and promo codes frequently. · Avoid peak season unless you book very early. It seems the peak season for Santiago travel is around July. · Get exclusive promo codes for HopeGoo app users.

The cheapest months to fly from La Serena to Santiago is October, when demand for travel is lower.

After crunching the numbers on our March flight calendar, it's currently cheapest to fly from La Serena to Santiago on March 2, 2026 with Sky Airline, with prices starting at US$42.

You can land at any one of the following hubs in Santiago, with La Florida Airport to Arturo Merino Benitez International Airport (LSC-SCL) is by far the most common option on this route: Arturo Merino Benitez International Airport (SCL).

The time difference between Santiago and La Serena is 0h.

Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your HopeGoo, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.