Santiago to Guayaquil Flights from HKD 143 incl. tax

Based on HopeGoo data, LATAM Airlines offers one-way fares as low as US$152 on Cheapest nonstop routes (e.g. SCL to GYE on Thu, Mar 5), while LATAM Airlines offers Cheapest nonstop round-trips from US$328 departing on Thu, Apr 2 and returning on Thu, Apr 9.

At the moment, you can catch a nonstop flight from Santiago to Guayaquil with the following airlines, including: LATAM Airlines Selected airlines are based on historical data collected from flight bookings users made on HopeGoo within the last 90 days.

It takes about 5 hours 18 minutes to fly from Santiago to Guayaquil.

By analyzing data from all airlines on the HopeGoo flight calendar, it looks like the best time to book a flight from Santiago to Guayaquil is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

Based on HopeGoo data in the past 4 weeks, there is 7 flight per week flying from Santiago to Guayaquil. You can check the weekly schedule for popular airlines on this route below: LATAM Airlines: S/M/T/W/T/F/S -- LA1446 (03:00)

To find best deals on flights from Santiago to Guayaquil, you can use various tools on HopeGoo: · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Thu, Mar 5, with one-way flights priced at just US$152. · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is LATAM Airlines. · Set up price alerts to easily monitor ticket prices without having to check every day. · Check HopeGoo flight deals and promo codes frequently. · Avoid peak season unless you book very early. It seems the peak season for Guayaquil travel is around January. · Get exclusive promo codes for HopeGoo app users.

The cheapest months to fly from Santiago to Guayaquil is October, when demand for travel is lower.

After crunching the numbers on our February flight calendar, it's currently cheapest to fly from Santiago to Guayaquil on February 19, 2026 with LATAM Airlines, with prices starting at US$156.

You can land at any one of the following hubs in Guayaquil, with Arturo Merino Benitez International Airport to Jose Joaquin De Olmedo International Airport (SCL-GYE) is by far the most common option on this route: Jose Joaquin De Olmedo International Airport (GYE).

The time difference between Guayaquil and Santiago is 1h.

Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your HopeGoo, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.