Santiago to La Serena Flights from US$9 incl. tax

Based on HopeGoo data, Sky Airline offers one-way fares as low as US$17 on Cheapest nonstop routes (e.g. SCL to LSC on Tue, Mar 3), while Sky Airline offers Cheapest nonstop round-trips from US$33 departing on Sat, Mar 7 and returning on Sun, Mar 8.

At the moment, you can catch a nonstop flight from Santiago to La Serena with the following airlines, including: Sky Airline LATAM Airlines Selected airlines are based on historical data collected from flight bookings users made on HopeGoo within the last 90 days.

It takes about 1 hour 9 minutes to fly from Santiago to La Serena.

By analyzing data from all airlines on the HopeGoo flight calendar, it looks like the best time to book a flight from Santiago to La Serena is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

Based on HopeGoo data in the past 4 weeks, there is 59 flight per week flying from Santiago to La Serena. You can check the weekly schedule for popular airlines on this route below: LATAM Airlines: S/M/T/W/T/F/S -- LA106 (09:38) LATAM Airlines: S/M/T/W/T/F/S -- LA100 (07:57)

To find best deals on flights from Santiago to La Serena, you can use various tools on HopeGoo: · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Tue, Mar 3, with one-way flights priced at just US$17. · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Sky Airline. · Set up price alerts to easily monitor ticket prices without having to check every day. · Check HopeGoo flight deals and promo codes frequently. · Avoid peak season unless you book very early. It seems the peak season for La Serena travel is around July. · Get exclusive promo codes for HopeGoo app users.

The cheapest months to fly from Santiago to La Serena is October, when demand for travel is lower.

After crunching the numbers on our February flight calendar, it's currently cheapest to fly from Santiago to La Serena on February 27, 2026 with Sky Airline, with prices starting at US$42.

You can land at any one of the following hubs in La Serena, with Arturo Merino Benitez International Airport to La Florida Airport (SCL-LSC) is by far the most common option on this route: La Florida Airport (LSC).

The time difference between La Serena and Santiago is 0h.

Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your HopeGoo, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.