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Driving along the Pan-American Highway (Ruta 5) is like tracing the spine of Chile—majestic mountains, endless desert plains, and glimpses of the Pacific coast unfold mile after mile. More than just a road, it’s a journey through landscapes that whisper adventure. For road-trippers, this stretch is pure freedom on wheels.
This hotel is a perfect blend of family-friendly and business-savvy! Nestled in Las Condes, just a 15-minute walk to Arauco Park Mall and KidZania Santiago, convenience is guaranteed. Enjoy top-notch amenities like the seasonal outdoor pool, spa treatments, and a kids' club to keep the little ones entertained. The executive lounge and business center cater to work needs seamlessly. Don’t miss the authentic Italian cuisine at Senso Restaurant or 24-hour room service. With free WiFi and valet parking, every detail is thoughtfully covered!
This luxury hotel in Las Condes is just minutes away from Costanera Center and Arauco Park Mall, making it super convenient! Enjoy top-notch amenities like an indoor pool, fitness club, and spa treatments, plus access to the executive lounge and 24-hour room service. Business travelers will appreciate the meeting facilities and express check-in/out. Rooms are equipped with iPod docks, minibars, and designer toiletries for ultimate comfort. Whether for business or leisure, this is your perfect stay!
This luxurious hotel is your perfect choice! Whether for business or family trips, it has all the facilities you need. Relax by the outdoor pool or in the sauna, while kids enjoy the play area and mini-golf. Catae Restaurant serves international cuisine, and 24-hour room service adds convenience. With a 24-hour business center and meeting spaces, it’s ideal for work trips. Plus, its prime location puts shopping and attractions just minutes away. A stay here is simply unbeatable!
Looking for luxury and convenience in Chile? This hotel is the perfect choice! Located in the heart of the new financial district, it features a small indoor pool, four dining options, and the famous Benatino Bar serving the iconic Pisco Sour. Explore nearby attractions like the sculpture park or San Cristobal Hill. With 20 meeting venues and top-notch amenities including a fitness center and spa services, it’s ideal for both business and leisure. Enjoy hassle-free travel with airport shuttle and valet parking!
Welcome to this luxury hotel in the heart of Las Condes, Santiago, Chile! Perfectly located near shopping centers and ski resorts, it offers ski-in/ski-out access, an outdoor pool, and a 24-hour fitness center. Enjoy diverse dining options at three on-site restaurants or unwind at the poolside bar. The stylish rooms feature iPod docks and minibars for ultimate comfort. With free WiFi, airport shuttle services, and concierge services, this hotel is ideal for both business trips and leisure getaways.
This downtown Santiago hotel is perfect for both business and leisure! Just minutes from La Moneda Palace, unwind at the spa with massages and facials, or stay active at the indoor pool and fitness center. Rooms are stylish with free WiFi and satellite TV—wind down at the bar after a busy day. Business travelers will love the meeting rooms and express check-in. Enjoy complimentary breakfast and 24-hour room service, ensuring every need is met effortlessly.
This 2024 award-winning hotel is your perfect choice! Located in Vitacura, Santiago, just a 4-minute walk to Casa Costanera, it's super convenient! Enjoy spa massages, an outdoor pool, and a fitness center to relax and unwind. With free WiFi and a 24-hour business center, business trips are a breeze. Love good food? Don't miss the international cuisine at Fronterizo Restaurant or the drinks at the poolside bar! The hotel also offers airport shuttle services and limousine services, making your stay extra comfortable. Whether for vacation or business, this place has it all!
This luxury hotel in Santiago's heart is just 12 minutes' walk from Farmacia Shopping Center, featuring an indoor pool and fitness center! Perfect for both business (with 24-hour business center) and weddings, rooms boast Italian Frette linens and 49-inch LED TVs. Enjoy free WiFi, unwind at the bar, or try 24-hour room service—every detail is designed for your comfort!
This 2024 listed hotel in Santiago's modern business district offers the perfect base to explore the city. With metro access to historic sites and surrounded by local restaurants and boutiques, you'll love the vibe. Enjoy amenities like a pool, fitness center, and convenient airport transfers plus laundry services. Rated 4.2, it's ideal for both business trips and family getaways!
This 2024 featured hotel is located in the heart of Santiago, just a 2-minute walk from Gabriela Mistral Cultural Center and 15 minutes from Santa Maria Clinic. Enjoy top-notch facilities like a fitness center, pool, and hot tub, plus free WiFi and a 24-hour business center. Dining options are plentiful, with Urbano 136 Restaurant offering international cuisine and 24-hour room service. The hotel also boasts 1,500 sqm of meeting space, perfect for events. The 291 rooms feature plush bedding and premium amenities for ultimate comfort.
Located in Providencia, Santiago, this hotel offers unbeatable convenience, just a 1-minute drive from Costanera Center and close to medical centers and Arauco Park Shopping Center. Enjoy the 24-hour fitness center and peaceful garden to unwind during your travels. Stay connected with free WiFi and multilingual services for a seamless experience. Rooms are equipped with LCD TVs and comfortable bathrooms, ensuring a home-like atmosphere. Whether for business or leisure, this hotel caters to all your needs with style and comfort.
This hotel is your perfect choice in Santiago! Located in Vitacura, just 5 minutes from Costanera Center and Arauco Park Mall, it’s super convenient. Enjoy spa massages, an outdoor pool, and a fitness center to unwind. With free WiFi and 24-hour front desk service, all your needs are covered. Dine on Mediterranean cuisine or relax with a drink at the bar. Whether for business or leisure, the business center and wedding services have you covered. Plus, free self-parking and airport shuttle make everything a breeze!
This hotel is the perfect choice for both business and family trips! Enjoy the indoor and outdoor pools and sauna to relax after a long day. With a kids' playground and child-friendly dining options, your little ones will have a great time. Conveniently located just minutes from downtown and shopping centers. Stay connected with free WiFi and utilize the business center for work needs, while 24-hour room service ensures you never go hungry. Planning an event? The hotel offers over 700 square meters of meeting space, ideal for conferences or weddings!
This hotel is the perfect blend of business and leisure! Located in the heart of Santiago, just a 4-minute walk to Costanera Center, shopping is a breeze. Enjoy top-notch amenities like a 24-hour fitness center and spa services, plus free WiFi and multilingual staff for a seamless stay. Dine on local and international cuisine at the on-site restaurant, or take advantage of 24-hour room service. The spacious rooms feature robes and coffee makers, adding a touch of home to your travels. Whether for work or play, this is your ideal getaway!
Nestled in one of Santiago's most vibrant districts, this hotel offers stunning mountain views and is surrounded by attractions like Bicentennial Park, shopping centers, and art galleries. Perfect for both business and leisure, it features a fitness center, outdoor pool, and indoor parking, along with convenient airport transfers. As a 2024 award-winning hotel, it’s the ideal choice for your next stay in Chile!
This cozy B&B is perfect for family trips! Just a 5-minute drive from downtown and hospitals, it’s super convenient. Enjoy free WiFi, 24-hour room service, and even childcare services for a stress-free stay. They also offer complimentary breakfast and airport shuttle, making everything hassle-free. The rooms are uniquely decorated with microwaves and flat-screen TVs, giving you all the comforts of home. If you’re traveling with kids, this is the ideal spot!
Looking for a luxurious and comfortable stay in Santiago? This hotel is your perfect choice! Just minutes away from shopping malls and attractions, it also features a relaxing SPA facility for your enjoyment. With 24-hour room service, an international restaurant, and a bar, dining is never a problem. Business travelers will appreciate the business center and meeting rooms. The rooms are well-equipped with free WiFi and minibars, ensuring a cozy stay. Come and experience it for yourself!
Everything you need to know about Pan-American Highway (Ruta 5)
Hyatt Regency Santiago is a top choice located just steps from Ruta 5, offering seamless access to the Pan-American Highway and major city attractions. The hotel features modern amenities, a rooftop pool with panoramic views of the Andes, and proximity to Plaza de Armas and Santa Lucia Hill. Guests can also book guided road-trip tours through the central valley, exploring vineyards, mountain passes, and indigenous heritage sites.
With its strategic location and cultural connectivity, it’s ideal for travelers seeking both comfort and adventure along one of the Americas’ most iconic routes.
Start your day in Santiago and drive south along Ruta 5 toward Valparaíso, stopping briefly at the Atacama Desert gateway for dune buggy rides and stargazing under pristine skies. In Valparaíso, explore the historic hillside neighborhoods, ride the funiculars, and climb Cerro Santa Lucía for sweeping Pacific Ocean views.
In the afternoon, head to Iquique for fresh seafood, or enjoy sunset concerts along the Peruvian coastline. Use local car rental services with guided tour options for safety and cultural insight. This route blends natural wonders, historical charm, and authentic coastal life—a true celebration of Chilean identity.
Scenic drives, cultural immersion, and coastal rhythms make this journey unforgettable.
Accessing downtown Santiago from the Pan-American Highway (Ruta 5) takes just 20 minutes via well-connected highways and urban expressways. Exit at Santiago Norte or use the Central Ring Road to enter the city center seamlessly.
For non-drivers, take the Metrobus line or use ride-hailing apps like Uber and Lyft from highway drop-off points to key locations such as Santiago Central Station or Providencia District. Many hotels along Ruta 5 offer complimentary shuttle buses for guest convenience.
With an efficient transit network, both self-drive and public transport users enjoy fast, reliable access. Santiago’s status as a transportation hub makes it a smooth transition point for travelers on the Pan-American route.
Speed, flexibility, and connectivity ensure a hassle-free urban entry.
Hotel Plaza San Francisco is a top choice in downtown Santiago, just steps from the starting point of the Pan-American Highway (Ruta 5). This modern boutique hotel blends Chilean architectural heritage with contemporary design, featuring an infinity pool on the rooftop offering panoramic views of the city and the Andes Mountains. Its prime location provides easy access to metro lines and bus terminals, making it ideal for travelers continuing south along the highway. The hotel also offers local guided tours, helping guests plan excursions to charming towns and scenic stops along the route, ensuring a seamless and authentic journey through Chile’s iconic corridor.
Key stops along the Pan-American Highway (Ruta 5) south of Santiago include Valparaíso, a vibrant port city famed for its colorful hillside neighborhoods and historic funiculars offering sweeping views of the harbor. Next, La Serena serves as the gateway to the Atacama Desert, where you can enjoy sandboarding, desert hikes, and world-class stargazing under pristine night skies. Don’t miss Coquimbo, known for its lush vineyards—visit local wineries to sample premium red wines from Chile’s Central Valley. These stops not only provide rest and supplies but also offer immersive experiences into Chile’s diverse landscapes and rich cultural heritage.
Optimize your day with a segmented itinerary: Start in Santiago, drive to Valparaíso (approx. 2 hours), spending half the day exploring the historic streets, street art alleys, and waterfront. In the afternoon, continue to La Serena, stopping briefly at the edge of the Atacama Desert to admire the dramatic landscape. Arrive in time for a night sky tour, one of the world’s premier stargazing experiences under crystal-clear skies. This plan combines urban culture, natural spectacle, and celestial wonder—maximizing the unique advantages of the Pan-American Highway (Ruta 5) while maintaining a balanced, enriching pace.
The Atacama Desert stretch between La Serena and San Pedro de Atacama offers breathtaking sunrises and sunsets. With vast, unobstructed terrain, golden light spills over salt flats and volcanic rock formations at dawn, while dusks paint the sky in vivid oranges and purples reflected on wind-sculpted pillars and dunes. Ideal spots include Cerro Colorado and Laguna Cejar, both featuring designated viewpoints perfect for photography and quiet contemplation. Additionally, the hilltop parks of Valparaíso provide stunning ocean sunsets, with the Pacific reflecting hues across the water. These moments combine visual grandeur with emotional depth, making them unforgettable highlights of any journey along the Pan-American Highway (Ruta 5).
Along the Pan-American Highway (Ruta 5), explore authentic culinary experiences beyond Santiago. In Valparaíso, savor Cazuela de Mariscos, a rich seafood stew made with freshly caught fish and shellfish, seasoned with local herbs. Head north to La Serena, where you’ll find Pinocha—a traditional corn-based baked pie filled with meat, crispy on the outside, tender within, best enjoyed with a spicy salsa. In Coquimbo, join a hands-on wine-making workshop at a family-run vineyard, learning ancestral techniques for crafting Chile’s renowned red wines. These experiences offer more than meals—they reveal the deep-rooted regional flavors and cultural traditions that define Chile’s diverse gastronomy.
For safe travel along the Pan-American Highway (Ruta 5), rent a car with comprehensive insurance and roadside assistance in Santiago, and download the official Chilean highway emergency app (SOS Ruta 5). Major cities like Valparaíso, La Serena, and San Pedro de Atacama have 24/7 mechanics stations, and many gas stations offer basic services such as oil checks and tire pressure adjustments. In emergencies, call Chile’s national highway hotline 130 or use GPS-enabled mobile alerts. Carry essential supplies including a spare tire, jump starter, and ample drinking water—especially critical when crossing the Atacama Desert. Regularly check coolant levels, engine oil, and brake systems to maintain optimal performance throughout the journey.
See what other travelers say about Pan-American Highway (Ruta 5)
Staying at Mandarin Oriental, Santiago was an absolute delight! Even though the room had a slightly older design, the service was outstanding—friendly, attentive, and always one step ahead. The pool area is stunning, clean, and perfect for relaxing. With Christmas approaching, the lobby was beautifully decorated with a gorgeous tree, adding a festive touch to our stay. As a honeymoon couple, we were treated to champagne and a small cake—such a sweet surprise! Breakfast was abundant and delicious, offering a great start to each day. The location couldn’t be better—right next to a major shopping mall and just steps from the sightseeing bus stop, making it super convenient to explore the city. And the view from the room? Absolutely breathtaking—panoramic views of Santiago’s skyline that made every moment feel special. This hotel truly delivers on comfort, charm, and memorable experiences. I’d definitely return.
Staying at The Ritz-Carlton, Santiago was an absolute delight. Located in the heart of one of South America’s most vibrant cities, the hotel offers a perfect blend of luxury and convenience. From the moment I walked in, the staff made me feel welcome with warm smiles and impeccable service—attentive without being intrusive. My room was spacious, elegantly designed, and offered stunning views of the city skyline. The bed was incredibly comfortable, making for a restful night's sleep. The on-site dining options were exceptional, with a delicious breakfast spread featuring both local Chilean specialties and international favorites. What truly stood out was how seamlessly the hotel connects to the city—just a short walk to shopping districts, cultural attractions, and great restaurants. It’s rare to find such high-end comfort combined with such authentic local charm. If you're visiting Santiago, this is the place to stay. A top-tier experience from start to finish.
This hotel exceeded all my expectations! The room was spotless, beautifully clean, and incredibly comfortable—right away I felt at home. Located in a safe, central area, it’s just a short walk to public transit and downtown attractions. I especially loved the breakfast spread: fresh fruit, granola, eggs, bacon, yogurt, and juice—all high quality and plentiful. There are tons of great restaurants nearby, so dining out is never an issue. As a frequent business traveler, I appreciate how well-priced this place is for the level of service and comfort. It’s rare to find such a perfect balance between convenience, safety, and value. I’ll definitely be coming back next time I visit Santiago.
Staying at InterContinental Hotels Santiago was an absolute delight! The room was spacious and impeccably designed, offering a comfortable and luxurious feel. Breakfast was outstanding—plenty of variety with fresh, high-quality options ranging from local favorites to international classics. The hotel’s prime location along the main thoroughfare made it perfect for photography, with stunning city views and great lighting throughout the day. Just steps away, there’s a lively street packed with restaurants, so dining out is incredibly convenient and diverse. I especially enjoyed trying the hotel’s house-made ice cream—it was creamy, flavorful, and refreshingly unique. Overall, this stay exceeded expectations. With such a fantastic location, excellent service, and top-tier amenities, it’s definitely one of the best choices in Santiago. Would highly recommend and will be back!
I stayed here during a conference, so rooms were fully booked and the price was on the higher side—around $300 per night. That said, aside from the cost, everything else was excellent. The staff went above and beyond with their service—friendly, prompt, and genuinely helpful. The facilities are top-notch: modern gym, well-maintained pool, and clean, stylish rooms. The view from the window is absolutely stunning, especially at sunset when you can see the entire Santiago skyline. The only downside was breakfast—it felt a bit lacking in variety. There weren’t many options, and despite what other guests mentioned, I didn’t see any cherries at all. Just basic fruits like apples and bananas. Still, considering the overall experience, the location, the comfort, and the service, it’s definitely worth it for the right occasion.
Located in the heart of Santiago, Chile, Hotel Plaza San Francisco offers a great central location with easy access to shopping streets and a wide variety of restaurants. The hotel has a vintage charm with well-maintained facilities—everything is clean and in good condition. The breakfast spread is generous and fresh, with high hygiene standards. One small downside: there’s no kettle in the room, which makes preparing tea or coffee a bit inconvenient. Still, the overall experience is excellent, especially considering the convenient location and the clean, welcoming atmosphere. Perfect for travelers who value comfort, cleanliness, and being close to city life.
My stay at NOI Vitacura was absolutely perfect—exactly what I needed to unwind in the middle of the city. The spa experience was outstanding: a warm indoor pool, dry and steam saunas, plus complimentary herbal teas that added a soothing touch. The staff went above and beyond with their friendly and attentive service. Breakfast was fresh and satisfying, but the highlight was lunch at Tramonto restaurant—rich flavors paired with breathtaking views of the Gran Costanera Center skyline. It’s rare to find such a peaceful retreat right in the heart of Santiago. This place truly offers the ideal escape without leaving the city.
Absolutely stunning hotel — I loved every single detail! Stayed in room 1803 on the 18th floor, and the view of the Andes and Santiago cityscape was breathtaking. Every morning felt like a treat just looking out the window. The cleanliness is top-notch, and while breakfast offered limited hot options, the fresh fruits and excellent selection of cheeses more than made up for it. The on-site restaurant was fantastic — delicious food and a great wine list to match. I also enjoyed relaxing in the warm rooftop pool on the 20th floor and using the well-equipped fitness center. Staff were incredibly welcoming and attentive throughout my stay. Perfect location, unbeatable service, and an overall experience that exceeded expectations. I’d gladly return and highly recommend this hotel to anyone visiting Santiago.
Staying at this hotel was a great experience. Located in the business district, it’s super convenient for getting around Santiago—just a short metro ride to downtown. The area feels clean and safe, even late at night. The hotel itself is modern and well-maintained with top-notch amenities. The room was spacious, spotless, and had a pleasant, subtle scent that made it feel fresh and inviting. The lobby design stands out with its sleek, contemporary style—very Instagram-worthy. We didn’t get to use the pool, but knowing it’s there adds to the appeal. Staff were friendly and responsive, making check-in and check-out smooth. Overall, the value for money is excellent—high quality without the high price tag. I’d definitely stay here again on my next trip to Santiago.
Le Méridien Santiago stands out as one of the top choices in South America. Located just a short walk from the city center, it’s incredibly convenient for exploring Santiago—public transit is nearby, and there are plenty of restaurants and shops within easy reach. The room was spacious, clean, and well-designed with excellent soundproofing and a comfortable bed that made for a restful night’s sleep. The staff were friendly and efficient throughout our stay, making check-in and check-out smooth. What really impressed us was the overall value—great quality at a reasonable price. If you're planning a trip to Chile, this hotel is absolutely worth considering. A standout experience!
Staying at this hotel was an absolute delight! The room was spacious, clean, and located on a high floor, offering breathtaking views of the distant mountains—perfect for morning light and sunrise moments. The service was exceptional; staff were genuinely friendly, attentive, and always ready to help with anything you needed. What stood out most was the unlimited bottled water—a small but thoughtful touch, especially during hot weather. The location is excellent too, just a short walk from the metro and downtown Santiago. It’s rare to find such comfort, convenience, and hospitality all in one place. I’d definitely stay here again and highly recommend it to anyone visiting Santiago.
Staying at The Singular Santiago was an absolutely unforgettable experience. The location is incredibly convenient—just a short walk from the city center and within easy reach of restaurants, shops, and attractions. The staff went above and beyond with their warm, genuine hospitality; every interaction felt personal and welcoming. What truly made my stay special was the surprise birthday celebration they arranged—complete with a lovely cake and heartfelt wishes. It was such a thoughtful touch that brought real emotional joy. The room lighting was a bit dim, but it added to the cozy, intimate ambiance rather than being a drawback. Overall, this hotel delivers exceptional service, a unique atmosphere, and incredible value. I’d highly recommend it to anyone visiting Santiago—and I’ll definitely be back.
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